Organic & Medicinal Chemistry Group

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Publications

Publications

- Dynamic Kinetic Asymmetric Ring-Opening/Reductive Amination Sequence of Racemic Nitroepoxides with Chiral Amines:  Enantioselective Synthesis of Chiral Vicinal Diamines.

Juan Agut, Andreu Vidal, Santiago Rodríguez, Florenci V. González.

J. Org. Chem. 2013, 78, 5717-5722.

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- Radical Mechanism in the Elimination of 2-Arylsulfinyl Esters.

Antonio Latorre, Irakusne López, Victoria Ramírez, Santiago Rodríguez, Javier Izquierdo, Florenci V. González, Cristian Vicent.

J. Org. Chem. 2012, 77, 5191-5197.


   Selected by ChemInform

- Stereoisomerization of alpha-hydroxy-beta-sulfenyl-alpha,beta-dimethyl Naphthoquinones Controlled by Nonbonded Sulfur-Oxygen Interactions.

Antonio Latorre, Santiago Rodríguez, Amit Jain, Florenci V. González, José A. Mata.

Tetrahedron 2013, 69, 2098-2101.

- Study of the stereoselectivity of the nucleophilic epoxidation of 3-hydroxy-2-methylene esters.

Antonio Latorre, José A. Sáez, Santiago Rodríguez, Florenci V. González.

Tetrahedron 2014, 70, 97-102.


Selected by ChemInform

- Fast methodology for the reliable determination of nonylphenol in water samples by minimal labeling isotope dilution mass spectrometry.

Neus Fabregat-Cabello, Ángel Castillo, Juan V. Sancho, Florenci V. González,

Antoni Francesc Roig-Navarro.

Journal of Chromatography A 2013, 1301, 19– 26.

  1. -Regioselective Ring Opening and Isomerization Reactions of 3,4-Epoxyesters Catalyzed by Boron Trifluoride.

Javier Izquierdo, Santiago Rodríguez, Florenci V. González.

Org. Lett. 2011, 13, 3856-3859.


   Selected by ChemInform

- Stereoisomerization of beta-Hydroxy-alpha-sulfenyl-gamma-butyrolactones Controlled by Two Concomitant 1,4-Type Nonbonded Sulfur-Oxygen Interactions As Analyzed by X-ray Crystallography.

Florenci V. González, Amit Jain, Santiago Rodrguez, Jos A. Sáez, Cristian Vicent, Gabriel Peris.

J. Org. Chem. 2010, 75, 5888-5894.

  1. -Influence of the Gas Atmosphere on the Deprotection of (Z)-gamma-Hydroxy-alpha,beta Unsaturated Esters.

Irakusne López, Santiago Rodríguez, Javier Izquierdo, Florenci V. González and Cristian Vicent.

Lett. Org. Chem. 2009, 6- 504-506.


Selected by ChemInform

- Highly stereoselective epoxidation of O-protected 3-hydroxy-1-nitroalkenes.

Amit Jain, Santiago Rodríguez, Irakusne López, Florenci V. González.

Tetrahedron 2009, 65, 8362-8366.


Selected by ChemInform

- Amidation through carbamates.

Antonio Latorre, Santiago Rodríguez, Javier Izquierdo, Florenci V. González.

Tet. Lett. 2009, 50, 2653-2655.


Selected by ChemInform

- Highly Stereoselective Epoxidation of alpha-Methyl-gamma-hydroxy-alpha,beta-unsaturated Esters: Rationalization and Synthetic Applications.

Irakusne López, Santiago Rodríguez, Javier Izquierdo, Florenci V. González.

J. Org. Chem. 2007, 72, 6614-6617.


  Selected by ChemInform

- Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain.

Florenci V. González, Javier Izquierdo, Santiago Rodríguez, James H. McKerrow, Elizabeth Hansell.

Bioorg. Med. Chem. Lett. 2007, 17, 6697-6700.

- Diastereoselective synthesis of gamma-hydroxy alpha,beta-epoxyesters and their conversion into beta-hydroxy alpha-sulfenyl gamma-butyrolactones.

Santiago Rodríguez, María Kneeteman, Javier Izquierdo, Irakusne López, Florenci V. González, Gabriel Peris. Tetrahedron 2006, 62, 11112-11123.


Selected by ChemInform

- Epoxides as useful synthetic building blocks.

Javier Izquierdo, Irakusne López, Santiago Rodríguez. Florenci V. González.

Rec. Res. Dev. Org. Chem. 2006, 10, 53-61.

- Asymmetric epoxidation of poor-electron olefins.

Santiago Rodríguez, Alberto Vidal, Juan J. Monroig, Florenci V. González.

Rec. Res. Dev. Org. Chem. 2004, 8, 13-28.

- Diastereoselectivity in the epoxidation of gamma-hydroxy alpha,beta-unsaturated esters: temperature and solvent effect.

Santiago Rodríguez, Alberto Vidal, Juan J. Monroig, Florenci V. González.

Tet. Lett. 2004, 45, 5359-5361.

Here you will find our latest publications:

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- Nitroepoxides as Versatile Precursors to 1,4-Diamino Heterocycles.

Andreu Vidal, Santiago Rodríguez, Florenci V. González.

Org. Lett. 2014, 16, 1752-1755.


Selected by ChemInform

- Synthetic Studies on the Preparation of Alanyl Epoxysulfones as Cathepsin Cysteine Protease Electrophilic Traps.

Antonio Latorre, Santiago Rodríguez, Florenci V. González, Bogdan I. Florea, Herman S. Overkleeft

J. Org. Chem. 2015, 80, 7752 -7756.

- Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action.

Santiago Royo, Santiago Rodríguez, Tanja Schirmeister, Jochen Kesselring, Marcel Kaiser, Florenci V. González

Chem. Med. Chem. 2015, 10, 1484-1487.

- Patent: Improved Cysteine Proteases Inhibitors EP14382283


- Patent: Improved Cysteine Proteases Inhibitors EP14382307

- Patent: Cysteine Proteases Inhibitors WO20081522178


- Catalytic enantioselective epoxidation of nitroalkenes.

Andreu Vidal-Albalat, Katarzyna Swiderek, Javier izquierdo, Santiago Rodríguez, Vicent Moliner

and Florenci V. González

Chem. Commun. 2016, 52, 10060 -10063.


Highlighted as an item of interest in OPR&D               Selected by ChemInform

- Preparation of Morpholines and Benzoxazines Starting from Nitroepoxides.

Estefanía Capel, Andreu Vidal-Albalat, Santiago Rodríguez, Florenci V. González

Synthesis (Feature Article) 2016, 48(16), 2572-2580.         


  Selected by Synform           Highlighted in Synfacts

- Lignoids Isolated from Nectandra turbacensis (Kunth) Nees (Lauraceae)

Víctor Macías-Villamizar, Luís Cuca-Suárez, Santiago Rodríguez, Florenci V. González

Rec. Nat. Prod. 10:5 (2016) 654-658.

- Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain

Antonio Latorre, Tanja Schirmeister, Jochen Kesselring, Sascha Jung, Patrick Johé, Ute A. Hellmich, Anna Heilos, Bernd Engels, R. Luise Krauth-Siegel, Natalie Dirdjaja, Lledó Bou-Iserte, Santiago Rodríguez, and Florenci V. González

ACS Chem. Med. Lett. 2016, 12, 1073-1076.

- Natural Products as Cathepsin Inhibitors.

Andreu Vidal-Albalat and Florenci V. González

Studies in Natural Products Chemistry 2016, Vol. 50, 179 -213.

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Hanneke L. D. M. Willemen, Pedro M. Campos, Elisa Lucas, Antonio Morreale, Rubén Gil-Redondo, Juan Agut, Florenci V. González, Paula Ramos, Cobi Heijnen, Federico Mayor, Annemieke Kavelaars and Cristina Murga

Biochem. J. 2014, 459, 427-439.

  1. --Development and validation of a liquid chromatography isotopedilution mass spectrometry method for the reliable quantificationof alkylphenols in environmental water samples by isotopepattern deconvolution

  2. -Neus Fabregat-Cabello, Juan V. Sancho, Andreu Vidal, Florenci V. González, Antoni Francesc Roig-Navarro. Journal of Chromatography A 2014, 1328, 43– 51.

- Regioselective Opening of Nitroepoxides with Unsymmetrical Diamines

Yazdanbakhsh L. Nosood, Azim Ziyaei Halimehjani, and Florenci V. González

J. Org. Chem. 2018, 83, 1252-1258.

- Design and Synthesis of Cysteine Protease Inhibitors.

Florenci V. González

Proceedings 2017, 1(6), 672.

- Quantum mechanics/molecular mechanics studies of the mechanism of cysteine protease inhibition by peptidyl-2,3-epoxyketones.

Kemel Arafat, Silvia Ferrer, Florenci V. González and Vicent Moliner

Phys. Chem. Chem. Phys. 2017, 20, 12740 -12748.


Selected as 2017 PCCP Hot Article